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MesoTV | Results from phase 2 peritoneal mesothelioma trial w/ combination therapy (VEGF and immuno)

I am very pleased to present to you our second line of MesoTV MesoTV is a program that was created by the Mesothelioma Applied Research Foundation. In response to the need to cancel our International Symposium on Malignant Mesothelioma, We recognized that countless were seeking information about treatment. The science behind malevolent mesothelioma word of local communities and information about the workings of the mesothelioma exerted investigate foot. This platform has been become possible by our generous supporters and sponsors. Thank you so much better. It is so important for us to be able to raising all this pertinent information to the community that we dish Dr Raghav. Thank you so much better for participating us today on this newest episode of MesooTV Happy to join. Thank you. Thank you. So you’ve created quite a challenge. For me, The discussion we’re going to have today is about probably the two hardest pharmaceuticals to declare in the following areas of mesothelioma. I know it’s, a mix of therapies, it’s bevacuzimab and atezolizumab, or so. If you would correct my inflection and then we can start in Yeah, the figures do deter getting more and more complicated as the years pass, but yeah the the first compounding medicine is bevacizumab and atezolizumab and then of course you know the next one is easier to Pronounce MCY m1 1, but we can call it m1 1 for short, Perfect. Okay, enormous, So I understand that this trial is strictly for patients with peritoneal mesothelioma. Am I compensate, or is it for all solid tumors? Yes, so this trial? You know when we designed this study Mary. You know we’ve found that there is a very big knowledge gap in understanding efficacy of drugs in patients who have peritoneal mesothelioma, and you know clearly, I don’t need to educate the target audience here. We know that peritoneal, mesothelioma and pleural mesothelioma are two definite diseases from an epidemiology view from the clinical challenges and presentations that these patients have down to surgical policies and approaches that we take towards these patients. The only thing that has been lacking in the field so far has been the coming towards systemic therapies. Where “weve been”, you know, acquiring from plural mesothelioma studies. You know, partly because of the scarcity, partly because of you know where these cancers are housed. But you know here at MD Anderson, we have a big GI center, where we have a dedicated multidisciplinary team towards care of peritoneal mesotheliomas and our pleural mesothelioma is housed in Thoracic Medical Oncology. So you know recognizing our “patients “, their unique needs and the fact that these sickness could be different even at a molecular stage. You know We are big-hearted proponents of doing dedicated investigate in rare and, in this case, an ultra rare tumor. So this study was alone designed for peritoneal mesothelioma. There was another cohort of pleural mesothelioma on this study, but it was a separate cohort than the peritoneal mesothelioma cohort So now for our patients with peritoneal mesothelioma. For this study, are you taking oil histology, epithelioid, biphasic and sarcomatoid? Yes, so there was no exclusion for any of these. You know we wanted to evaluate this in all our patients. Now, of course, you know, the experiment does manifest the dispensation of what we see with regards to these histologies in specific populations, And this trial was designed for patients who are either not candidates for surgery or following a surgical. Relapse. Yes, so unquestionably not candidate. For a curative meaning, surgery and about 60 of our patients have had some sort of cytoreductive surgery and HIPEC previously, which is consistent with what we check out in the community. And you know there were some cases that presented de novo with ailment. That was never a candidate for surgical resection. So is there the reporting requirements for these patients to have had the standard therapy of Alimta cisplatinum, or can cases enroll directly into this trial , not having had a platinum Right? So this was a second line study Mary, so cases had to have progression or antipathy to a platinum, pemetrexed based treatment, so both the pharmaceuticals Now Avastin was not mandated, but it was also not an exclusion criteria or bevacizumab was not mandated or was not an exclusion Criteria – Okay, good, so that’s important to know. So such is two relatively recent treats and I’m not sure that the patients that will be listening to this series are familiar with the mechanism of war and the type of drugs, because these are quite different from chemotherapy. So would you like to talk a little bit about the bevacizumab first and then we can go into the other drug Sure utterly And if you’re okay with it. Maybe I’ll really try to explain both those mechanisms sort of together. So bevacizumab is a very common drug. It’s an older dope. You know this is a drug that hinders the vascular, epidermal expansion factor pathway. So you know this is the pathway that should contribute to angiogenesis or blood vessel constitutions that that assist cancer swelling. So this narcotic restrains those new blood vessel formation that helps cancer growth, and this is a drug that has been approved in numerous tumor sorts: lung cancer, colon cancer amongst other, and it has been demonstrated good activity in combination with chemo. Now there is no evidence where this dope is used by itself. You know the rationale for using this dope in malevolent peritoneal mesotheliomas is. We know that these are vascular and VEGF high-pitched tumors. You know there has been a a number of studies that have been done for mesotheliomas with VEGF agents , not exclusively bevacizumab, but other negotiators that have not shown any promising incremental advantage in general. You know there was a study of bevacizumab here in the us that didn’t show any better activity than chemo. There was a French study, the MAPS study which actually use bevacizumab in pleural mesotheliomas in firstly route treatment with carbo Alimta. It did demo some improvement in progression, free existence and overall survival, but clearly that study was specific for pleural mesotheliomas. Too that study did have a maintenance bevacizumab arm, so you know you got chemo with bev and then you still got some treatment versus you had nothing. So you know there were certain aspects of this study, so even though there is a VEGF signature in mesotheliomas, let me introduced it this way: VEGF cares by themselves are not uber effective in this disease, So they need something else to work with Now. Atezolizumab is a newer drug and this is the same class of drugs as immunotherapy, the so called immunotherapy doses And precisely to give people an idea of what exactly these immunotherapy dopes are. So you are familiar with, recollect: cancers are foreign to the body, so the immune arrangement always wants to destroy them, but there are multiple methods in which the cancer shuns the immune structure and one of those spaces is called the pd1 pdl1 pathway. So, basically, what the cancer cells do is they express this molecule called pdl1, which is called programmed fatality ligand and on the immune cells? There is a receptor for these, which is called the pd1 and naturally the reason for having that on the immune cells. Is you know whenever you get infected your immune system revs up, but you need a mechanism to decrease that immune organization. Otherwise, after every illnes, you’ll start developing infections, which are called autoimmunity cancers, in which you know the immune system starts attacking your own body. So the body has developed this mechanism of this pd1 molecule where a revved up immune organization gets checked, But cancers exploit this mechanism by suppressing the immune method uncommonly and that’s why they can proliferate. So you know a lot of drugs like pembrolizumab or nivolumab or atezolizumab in such cases target this pd1 mechanism right, so what they do is they uh bind to these ligands and they don’t allow that pd1 to be activated. So, in a way, you’re taking the break off the immune system and allowing that immune plan to assault the cancers. Now the rationale for combining these two cares is in mesothelioma per se. We have tried just like bevacizumab, “weve tried”. You know single negotiator, immune cares and the response paces are there. There are some patients who benefit, but they’re very suboptimal, sub 15 response rates in the majority studies and in peritoneal mesothelioma per se. The data is extremely limited because most of the studies have been done for pleural mesothelioma, So the reason why we wanted to combine these two stimulants is because bevacizumab can modify the tumor micro environment and remained unchanged from immune suppressive environment to a immune, feelings environment. So what it does is bevacizumab has been shown to increase these foreign antigen introductions on cancer cells and when cancer cells present these antigens, and now you bring in a drug that can take the breakings of the immune plan. Now it’s a perfect mechanism. You have lots of bad antigen, and then you have these immune cadres that are now triggered and they can collide together to create responses. So that’s the principles of the combining – and this combination is already FDA, approved in treatment of liver cancer or hepatocellular cancer. So in liver cancer, same tale, VEGF stimulants have some undertaking immune inhibitors like pd1 or pdl1. Drugs have some undertaking, but when you combine them together, there’s a synergistic effect, so that’s, that was a potent combination in liver cancer and that’s. Why we chose to do this in peritoneal mesotheliomas, Which was lucky for the peritoneal mesothelioma patients. As well because the toxicity and dosing had already been worked out, so you sort of had a clean slate to produce now into the clinic. So how are these stimulants dispensed Are these IV or are they by a pill model? How do you give these doses? So these are IV stimulants. They’re, sacrificed once every three weeks about an hour infusion each And how long does this study continue? How long will you get the two medications, So the study was designed to continue the treatment till either toxicities arise that are unacceptable or intolerable in individual patients or till the time you progress. So there was no definite period of this care and you are familiar with, as “youre seeing”, from the results which you know we’ll be discussing, which were presented at ASCO this year. Some patients have been on study for about two years, two and a half years. Pretty much the duration of the study so far That’s great When they initiate this ordeal. So you start the treats you can you have the one cycle, two cycles/seconds? Is it after the second or the third cycle that you are able to scan to take a look to see whether this medicine is working for them Yeah? So after three cycles, so every nine weeks the checks are every nine weeks? Okay, great And you do a regular CT scan to assess for response Yeah. Absolutely all the responses were according to the standard, RECIST criteria, which is the standard radiographic criteria we use for any other malady, largely Okay, and then I approximates my next question would be what kind of toxicities are you mentioned and individual patients should be aware of Right. So we treated about 20 patients of peritoneal mesotheliomas on the study Mary, but you know at the same time, we had also launched this rare cancer program, so there were other rare cancers that were treated with the same combination, so in totality we had about 120 cases That we treated with this combination and irrespective of this ailment feature, the safety signals were very similar and overall, the study was very well accepted, at least for our mesothelioma patients. Most toxicities were pointed one gradation two, The more common grade. Three toxicities were hypertension, which forms part of the bevacizumab medication and some anemia, but they were seen in about 40 percent and 10 cases respectively and in most cases they were managed very easily. The anemia was not a major fus for therapy continuation and neither was hypertension because you could administer it actively by antihypertensive remedies About two cases of studies and research did have an immune, interceded harmful occurrence. So you know like we were talking about you once you rev up the immune organization. It can have autoimmune effects, so those two cases did develop immune mediated side effects for which we had to stop the treatment, but otherwise for 18 cases. Treatment was continued without any problems. Wonderful, So what is your next design with this trial? So, of course, I suppose the first step is to make this data out and available to everyone, and you know, peritoneal mesothelioma is a very rare tumor. I strongly believe that we need collaborative scientists to do larger tests in this disease, but for now this is one of the best available evidence. You know that we have with regards to activity of IO, immunotherapy or combination of IO immunotherapy in peritoneal mesotheliomas. There are some patients that get treated with other immune checkpoint inhibitors, as has been you know, done for pleural mesotheliomas. I think that atezo and bevacizumab they were perhaps better stood. You know, of course you can’t. You can’t compare two different troubles, but if you look at it overall, I think this treatment was very well abode compared to other combinations of IOs immunotherapies that have been done in mesotheliomas and, of course, our our efficacy develops seem to be significantly better than What we’ve seen with other IO combinings or IOs, so I strongly would consider use of this medicine as a part of continuum of charge. Now that doesn’t mean the work is done because you know our results established tumor, established, tumor responses in about 40 patients and some tumor response in about 50 of individual patients. So there’s still a long way to go, so all newer trials and more rational combinings are needed, but for those that are not able to participate on clinical troubles, I think this represents a awfully viable and safe standard of care. We have been discussing this with the NCCN guidelines body to try to actually you are familiar with. There is no good guidelines for peritoneal mesothelioma, either ways discussing with them about about including you are familiar with, guidelines for peritoneal mesotheliomas, so that you patients can get the most appropriate care. That’s available out there And of course we are trying to see if we can move that is something that a greater trial or even earlier word of adjusting. Because, frankly, the outcomes in the study were much better than what we would have even expected. Out of. First line chemo Right, so I guess you know that’s always their own problems with a uncommon sicknes, and you know now we have a super subset of a rare disease with peritoneal, so you are familiar with getting the numbers that they’ll be statistically significant to move. This into you know an FDA approval process is going to take some exertion and, as “youve said”, it’s going to make quite a bit of collaboration. So you are familiar with, I be understood that as the role of the Foundation to sort of insert ourselves in the middle of this and try to get everybody to the table, and you know advancing the regimen and actually trying to get more collaboration. More collaborative events among you are familiar with those medical oncologists that are interested in peritoneal meso, because you really are a handful. You know, and I don’t mean a handful difficult but a handful There’s so few of you that you know it seems that you know if we could get everybody to the table together again and start to discuss what needs to be done in This disease, we can, as you said, get some standardization which has been lacking for the 20 plus years. I’ve been in this disease that we need to move forward Great. So thank you for doing this trial. I know with something with a small disease like this: it’s hard to get those figures that you need. So congratulations. I’m sure it was quite an effort. So thanks for coming . .

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Lancelot Guide 1 | What’s more important than Dash? | Master the Basics | Lancelot Gameplay | MLBB

what’s more important on Lancelot aside from Dash? in this mobile fictions steer we are going to talk about everything you need to know when using Lancelot also included the right and wrong decisions that I established on this recreation to everyone who wants to join our giveaway Hit Like, Share and Subscribe then observe your ID# and In Game Name then bark or protagonist that’s worth 500 Diamonds and most importantly you must finish every video I will randomly select 4 champions and announce it every 1st week of the month so if you are not yet agreed, affected subscribe and the notification buzzer ok, let’s go! in this game, this is the Emblem that I worked Assassin Emblem with Movement speed, Physical Pen and Killing Spree because Lancelot typically dives on towers that’s why Killing spree is good on him and when it comes to this game, us to be able to do the Funnel Lancelot and if you still don’t know what Funnel is, you can watch it on the Funnel Rotation Guide that I made and when it comes to Lancelot, the 1st thing you need to know about him is the 2nd skill you will notice here there are 3 triangle on Lancelot’s 2nd knowledge and each triangle distributes expense when an opponent is on 1 triangle, they will receive 1 mar and when they are inside 2 triangles they will also receive twice the damage and if they step on 3 triangle they will receive 3 impairs to understand more, if the foes are on the edge they will only receive 1 mar and if they are between 2 triangles they will receive 2 shatter and when they are in the middle that’s the only time they will receive 3 shatterings that’s why as much as possible you must knock your 2nd science on the middle part to increase it’s impair but you too need to remember that the damage likewise abbreviates when they are more foes hit by it you will see on this clip, the damage is higher if there’s only 1 hero that is hit by 2nd skill that’s why if you simply have 1 target you’ll be able to kill them faster aside from that there’s also a gradual on his 2nd talent 0.5 seconds slow on each triangle that’s why if the middle-of-the-road character thumps the slow period will be longer when it comes to Lancelot’s 1st talent, you can use it to dash on antagonists when you are made an enemy they will receive a mark whenever you dash on antagonists without distinguish, the cooldown of 1st ability resets but if your 1st ability didn’t made or you scoot on a hero with a trade mark, the 1st skill will be on cooldown when it comes to this game, you will notice that the foes already took my red tan that’s why we need to go to our next objective, the Crab on bot corridor and because Zhask is so boosted, that’s why this happens if you notice there, I exerted dash a few goes those sprint are so important for Lance’s passive whenever you dash Lancelot will gain additional 10% Damage it can reach up to 30% additional detriment that necessitates when you scoot three times, Lancelot will administer more injury aside from that you will likewise see above the regen how many dash you already did and because it only lasts 4 seconds that’s why you need to flair again if you don’t want it to reset when it comes to Lancelot’s Ultimate, that’s another hasten that intends he will also receive 1 load of passive aside from that you won’t hit by talents when you ultimate and it will deal big expense if it thumps the enemy when it comes to Lancelot’s combo, it’s important to get close to your target firstly if we are going to look at what happen there I use the jungle glide and minion to get close to Kimmy and when you get close to the enemy, do a basic attempt firstly and when they move a certain distance that’s the time you use your 2nd science and eventual and because Atlas doesn’t have a mark hitherto that’s why you can still dash on him and to get close to Atlas again, I expended another minion to dash in you need to remember, as much as possible don’t let your 1st skill cooldown if there are targets that doesn’t have stigmatize, it’s better to smash on it firstly now you will notice on this game the adversary red buff is already open and because we have a lead that means we can conquer aside from that, Lancelot is one of the strongest early recreation heroes but as much as possible you must have person with you if you are invading or ganking now we are going to fast forward on the boring parts before we continue the video, I want to shoutout Alex the Gamer, Dave Galinato and Ghiann Galicia whoever is the 1st three mentions on every video, I will shoutout on the next video so if you are not yet subscribed, affected subscribe and the notification bell if you notice on that teamfight formerly Lancelot’s 1st talent receive a cooldown it will be harder for you to get in or out that’s why as much as possible you must select your target properly if you will let your 1st knowledge get a cooldown you must be sure that you can burst the enemy aside from that you can also cast the 1st or ultimate while expending 2nd ability because it has slow that’s why you can easily target the enemy and because we’re able to kill them that means we can already take the tower you too need to remember, even if Lancelot is strong in early play you should not focus on teamfights as much as possible you must focus on objective whichever strategic objectives you are able to make, that’s the teamfight you are able to engage another thing you need to remember about Lancelot’s Ultimate if the foe is too far you can use his ultimate to get close you need to remember you must reset the 1st skill’s cooldown don’t let your first skill receive a cooldown specially if it’s just the start of a teamfight Lancelot’s first skill is not easy to aim that’s why it’s really important to make it hit the antagonist don’t force your soul in click the 1st skill too fast it’s important to aim it accurately when it comes to item build, this is the item build that I judge suits Lancelot best because his shattering increases whenever you dash then when you get close the enemy you need to do a basic onrush that’s why Heptaseas is so good and for additional injury and Burst, Blade of Despair and Endless battle is good and when it comes to the last item, you can change it depending on the situation you will notice here that Turtle is up but because the adversaries are close that’s why we can’t just take it but when I saw Khufra zoned out the opponents that’s why I can take sea turtles fast another thing you need to remember when you are using Lancelot you are able to always target the damage dealer and the squishy heroes of the opponent you can pass thru the antagonists in front or the cisterns to reach the enemies at the back but as far as is possible don’t target the tank first if you notice there, because my first talent didn’t reset it’s cooldown that’s why I wasn’t able to erupt Zhask if my 1st science resets.Even if my ultimate didn’t affected, I can still dash in on Zhask then basic assault then dash out and because I was too greedy that’s why they were able to kill me another thing you need to remember when it is necessary to Lancelot’s 2nd skill you can use it to dodge the enemies skills but the timing is so important you must time it perfectly with the opponent skill to dodge it I hope you learn a lot from that Guide and if you have a guide that you are willing to to conclude, time criticism down below and I’ll try to make one about it and because you finished the video I want the winner of our Giveaways are the ones watching until the end for me to know if you really watched until the end you need to look for the Keyword comment the Keyword along with the ID #, In recreation identify and Skin the more Keyword you have the more chances of winning so if you are not yet subscribed, reached subscribe and the notification buzzer ever remember, if you want to improve # justmasterthebasics I’m out

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The Mesothelioma Center Presents: Health & Wellness with Faith- “Should You Use a Juicer?”

Hey guys it s Faith with the Mesothelioma Center. Today I’ve got a brand-new health and wellness video for you And we re going to be talking about juicing and whether or not it s a better option than precisely eating produce in its natural state. Now juicing has become reasonably classy in cancer treatment. Lately, A parcel of survivors, including the mesothelioma survivor Paul Kraus, have attributed some of their success to their juicing regimens. Now it’s a great way to get a lot of nutrients in a small glass, but is it actually better than only gobbling the return or the vegetable? Today we’re gon na be looking at some of the pros and cons Pros of Juicing Juicing s main advantage is that it provisions a big pop of nutrients. Without concluding you physically eat a full meal In a little cup, you can get a ton of vitamins and minerals, which is great if you’re experiencing nausea or loss of appetite. The downside is that juice isn’t as calorically thick-witted as a full illustration of menu, so you shouldn’t rely on juice, as your only beginning of nutrients Now juicing might also be able to help break down these nutrients in a more efficient manner. This is great in theory, but studies haven, t proven it hitherto. Juicing likewise can help. You incorporate a wider variety of fruits and vegetables into your diet, that is vital because each type of produce has a unique nutrient profile. The Harvard University School of Health recommends juicing. As a way get in a few of your nine recommended performs of fruits and vegetables every day, If there’s something you’ve thought about trying, but are a little afraid of it like kale or papaya, discard it into the juicer You might just like It Cons of Juicing When you juice a outcome or a vegetable, you do lose most of the fiber And the fiber is extremely important for absorption and for remain full. You can counter this, however, by go some of the paste and pioneering that back into the juice. Now, when you juice, you likewise tend to lose the outermost part of the fruit, which is the most colorful and therefore the most nutrient dense. That signifies by juicing. You do lose out on some of the carotenoids and flavonoids thathelp protect your body from cancer. Juicing can also get a little bit expensive Because some of the bottled liquids are not as nutrient thick-witted as the raw stuff. You’re encouraged to buy your own juicer as well as a weekly supply of fresh create. This can get a little expensive, but if you do plan to do it on regular basis, it’s definitely a worthwhile investment. There are your pros and cons of juicing. If you ve ever tried a regimen or if you’re curiousabout, it come on over to asbestos com, and let us know See you soon:.

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Gatotkaca Guide 1 | How to Make a Burst Damage Tank ? | Master the Basics | Gatot Gameplay | MLBB

how to establish gatotkaca treat flare impairment even if he is a tank in this mobile legends navigate, we are going to talk about everything you need to know when using Gatot also included the right and wrong decisions that I made to everyone who wants to join our giveaway Hit Like, Share and Subscribe then note your ID# and In Game Name then skin or hero that’s worth 500 Diamonds and most importantly you must finish every video I will randomly adopt 4 wins and announce it every 1st week of the month so if you are not yet subscribed, touched subscribe and the notification bell ok, let’s go! in this game, this is the emblem that I used tank badge and more on physical security that’s because of Gatot’s passive then Concussive bang to deal more impair that’s also the reason why I selected Execute spell, for additional burst shattering but you are able go for Vengeance in this game we are gonna do the side lane Gatot and because the enemy team will do the 1-2-2 rotation that entails I will face 2 heroes here that’s why we are gonna do the basic rotation on top lane as much as possible we are just going to clear the brandish and farm jungle when it comes to Gatot’s talents, the first thing you need to remember is his passive whenever his hp comes low, his physical defense gets higher apart from that, whenever Gatot receives shatter he will have a Rage the Rage is the one below his HP to understand more about his passive, you will see on this clip the damage dealt to you must be atleast 1500 to activate the passive when that Rage becomes red, your next essential onslaught will cope burst impair and you will receive HP the good thing there, if you have high justification, you’ll be able to max the Rage without coming low-pitched HP you will see here, even if the damage of the turtle comes lower, he still just needs 6 smacks to activate the passive that signifies the computation on the damage that will be dealt by your foes are based on their skills when it comes to Gatot’s 1st knowledge, when you sounds it, it will once administer impair aside from that, whoever stays on that path will still receive injure it also has 40% sluggish when it is necessary to his 2nd science, he will charge it and whoever is hit will be taunted the enemies that are razzed will be forced to do basic attack on you but they can still remove it with sanctify this is one of the skills that was buffed on Gatot before, the longer service charges the longer the Taunt now even if the charge is low the heckle is to continue to 1.2 seconds that necessitates when you razz the adversary you can already do the combo on them Ling and Khufra rotated early, but notice the positioning of Khufra here because of the very nice position of Khufra that’s why he was able to catch Wanwan readily the only problem is Ling should’ve waited for the bigger Crab because they revolved early that’s why he wasn’t able to get the bigger Crab yet when it comes to Gatot’s ultimate, he will jump on an expanse and whoever is hit will be knock up everyone in the centre are likely to be thumped up longer and everyone around are likely to be drew in the middle but the good thing about that ability, if Gatot has higher Magic Power that skill will administer more injure if you notice it will treat +300% Total Magic Power if you notice the combo that I did, after thumping my 2nd science I utilized my Ultimate that’s good to meet your ultimate knock you need to remember, if you weren’t able to make it punch the damage will be squandered that’s why Gatot is good along with heroes with crowd control to be able to determine the Ultimate punched here, the adversary red buff will respawn but you need to remember, you should not just go in I’m waiting for Ling if he will help us make the foe red enthusiast this is one of the mistakes tanks do when they check an antagonist they will rush to the enemy if we are to be able to catch it the only problem is even if you’re able to catch them if you don’t have shattering you still won’t be able to kill them and because the turtle is open, we can also take it one of the ways to take the turtle is to realise the foes go away from it and as much as possible you must have a vision on the Turtle so that the enemies won’t easily take it now we are going to fast forward on the boring roles another thing you need to remember when you are using Gatot when you build the Rage into cherry-red as far as is possible you must hit the basic attack because it ends rapidly, if you are not receiving a damage, either basic assault or skils the Rage will be squandered here, because Selena’s arrow didn’t touched that’s why I didn’t continue my ultimate it’s better to be ready when the antagonist was stunned and because we’re able to kill the Wanwan, we should now make objective we also need to pressure this thoroughfare to be able to rotate faster when it comes to item build, this is the item build that I believe suits Gatot Concentrated Energy and Holy Crystal is good to have sustain and burst damage the last 3 items depends on the situation you can select from this items depending on the situation if you want to focus on having damage or focus on being a tank but the most important thing is to buy the Concetrated energy and Holy Crystal you will see last-minute how strong the sustain of Gatot if he already has both of those entries before we continue the video, I want to shoutout Jcrhea Marcos, Charles 666 and Renalito Reyes whoever is the 1st three statements on every video, I will shoutout on the next video so if you are not yet subscribed, made subscribe and the notification bell I hope you learn much from that Guide and if you have a guide that you want me to do, only criticism down below and I’ll try to make one about it and because you finished the video I require the winner of our Giveaways are the ones watching until the end for me to know if you really watched until the end, you need to look for the Keyword comment the Keyword along with the ID #, In competition epithet and Skin the more Keyword you have the more chances of winning so if you are not yet agreed, affected subscribe and the notification buzzer ever recollect, if you want to improve # justmasterthebasics I’m out

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Mesothelioma Survival: A mesothelioma survivor’s recount of finding out he had Cancer

You you well to be told, I have cancer and simply a short time to live is devastating, but when the cancer is an accidental find, while experiencing minus her abdominal surgery, the surprise was all the more profound and while my immediate reaction was fear and deep sadness, My wife reacted to the dire situation in another way we both had a deep interest in natural state and despite the surprise of the diagnosis I remember her asking me where can i buy some organic carrots to start juicing today her positive sentiment regarding the possibilities of Healing led our cancer journeying right from the most immediately the initial surprise had worn off. I was determined to give myself the maximum opportunity to heal by checking the diagnosis as a message to redirect my life. I am talking about researching my disease and soon realized that, while the mesothelium survival statistics were very poor and very few existed that, instead of giving in to despair and hopelessness, I could do much to help my situation and to give my figure the best possible chance to Control this illness and to maintain my quality of life, you you, you.

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ГАЙД ГВИНЕВРА MOBILE LEGENDS / ГВИНЕВРА ГАЙД 2021 / ГВИНЕВРА СБОРКА

0: 00: 00.010, 0: 00: 04.390 you had some kind of tricks yourself 0: 00: 01.510, 0: 00: 06.370 start you protruded from the very beginning at I had some kind of tactics and I did it adhered to everyone hello friends the girl who cosplays Alice from “the two countries ” supernaturals, the owner of “the worlds largest” stylish noble haircuts of the 17 th century guinevere the same cute young lady who delivers a bunch of problems as at the beginning competitions and pour today we will meet her closer inviting her on a date where we are find out who she is and how to dance her before watching you helped me out a great deal there you are now subscribe to the channel like and write what I could miss watch this issue to the end at the end will be a little doctrine drove[ music] let’s start with the structure before each guidebook and I make a link to what is with this assembly very convenient for me to play personally if you have your options boldly offer them them with a excite I will be addressed so the first boots of the caster pay us plus 15 supernatural penetration and plus 40 movement speed second item this is a clock of demise+ 60 spell power plus 615 streets and plus 600 mana third the subject of the same hall by lightning yields us a plus 75 sorcery ability plus 300 mana and plus 10 skill cooldown 4 piece is the disaster cashier leaves us plus 70 magical superpower plus 100 mana+ 6 mana regeneration plus 10 recharge skills 5 subject is a wand of genius yields us plus 75 spell capability and plus five to the speed of change last object or as it is also called the final clothe yeah it’s crab wings plus 150 supernatural strength and plus 500 health but also in progress plays, you understand that the adversary “ve got a lot” mar, then you can replace some of the parts of magical subject to protection like the shield of Athena, it shortens magical impair or old cuirass she abbreviates physical damage[ music] I rarely celebrate superstars’ affections, but now slightly different case guinevere with a series of successful criticizes passive science increases red divest along the growth of which it is in light-colored jump inflicts more significant injure than it was before if the opponent will try to get away from you, I is clear that he loses by willpower then this one the last climb is not enough to cut length he can also finish off the opposing first the ability of our fighter mustered newspaper shoots a magic ball in a straight line causing damage to the adversary, the cooldown of this capability about three seconds which allows her restrain other soldiers who do not have well at great distances for example die fortres is storied on their slips can only be safely worth complementing the final attempt Thank you who said above the damage from 1 ability this will significantly increase your a chance both to be completed the antagonist and imposing additional humiliation on him in taking away his precious state second ability it is a jump to the specified area but it is not only a start onslaught in the amount that throws up the antagonist justification him impair after why do not hesitate to finish off first ability and auto attack too after Obama’s jump in the family is a must close to the opponent because you can easily to escape leaving the opponent his hologram on the memory of the wasp is easy for him to pluck from him in either area is very cheating and useful skill that makes leaved such a charming girlfriend what it is also double flee in case withdraws you do not need to say that is, you are not only what did you come up with from the enemy so you likewise teleported about the same distance once again in time for this venus surroundings himself with spell clods from the first cleverness that revolve around her cause damage to everyone lucky who happened to be next to to her, to be honest, this is the whole ulta but if you jump on adversary and not yes, and at this moment when is he are likely to be thrown to mash the ult then he will no longer fall to the ground but will suffer all the damage you do to him apply because we all know that if you were torn off the soil, then you immediately become immobilized and disadvantaged mainly of course the second skill it is currently working rare cases when it goes through exactly being near with the opponent because then its good-for-nothing supports and he can safely leave through flashing or some of their skills[ music] if you look in general, it is due to the fault 0: 04: 34.060, 0: 04: 37.960 about a very interesting fighter to implement 0: 04: 36.550, 0: 04: 40.270 which can be different 0: 04: 37.960, 0: 04: 42.849 she get you and defended will come out epson can 0: 04: 40.270, 0: 04: 45.280 stand up looking against who of course 0: 04: 42.849, 0: 04: 47.259 however her health is low 0: 04: 45.280, 0: 04: 49.030 is sometimes very bad peculiarly 0: 04: 47.259, 0: 04: 51.099 if you start to believe in yourself and 0: 04: 49.030, 0: 04: 53.650 you fly to where the fatty 0: 04: 51.099, 0: 04: 55.990 guys and little girls weren’t waiting there 0: 04: 53.650, 0: 04: 58.360 is basically a strategy here to run up 0: 04: 55.990, 0: 05: 00.550 take away a piece of hp and move away 0: 04: 58.360, 0: 05: 03.190 that is, provoked to fight and left 0: 05: 00.550, 0: 05: 04.990 or vice versa, we flew under the tower 0: 05: 03.190, 0: 05: 07.599 shared injure from the ultimate and quickly 0: 05: 04.990, 0: 05: 09.819 attracted back myself personally for a very long time 0: 05: 07.599, 0: 05: 12.310 shelved the game on it because hear 0: 05: 09.819, 0: 05: 14.409 how others frisk it to me for some reason 0: 05: 12.310, 0: 05: 17.949 it seemed that for me she would be extremely 0: 05: 14.409, 0: 05: 20.229 difficult to learn e.g.Chong is wrong 0: 05: 17.949, 0: 05: 22.270 was not given no matter how I sold him a 0: 05: 20.229, 0: 05: 24.699 now with this friend the dialogue started 0: 05: 22.270, 0: 05: 27.219 very quickly and she began to answer 0: 05: 24.699, 0: 05: 29.789 I love literally 3 rinks a 0: 05: 27.219, 0: 05: 31.810 I didn’t even give grows 0: 05: 29.789, 0: 05: 33.729 a significant number of boxers 0: 05: 31.810, 0: 05: 35.830 is the ability to distribute by faces and 0: 05: 33.729, 0: 05: 38.469 ability to escape through cleverness 0: 05: 35.830, 0: 05: 40.990 now she has it all is the main thing on 0: 05: 38.469, 0: 05: 43.509 at first at least before buying 3 0: 05: 40.990, 0: 05: 45.969 pieces is not hop at all and everything because 0: 05: 43.509, 0: 05: 48.430 I repeat that she is not rich in health 0: 05: 45.969, 0: 05: 50.259 and in general if you look at it like that 0: 05: 48.430, 0: 05: 52.150 guinevere is still the hero plays for 0: 05: 50.259, 0: 05: 54.159 which needs to think a little onward 0: 05: 52.150, 0: 05: 56.319 perpetually observe your actions 0: 05: 54.159, 0: 05: 58.539 minimap is a character you can 0: 05: 56.319, 0: 06: 00.879 boldly through the second skill check the bushes 0: 05: 58.539, 0: 06: 03.129 not anxious that the foes waiting for you there are for 0: 06: 00.879, 0: 06: 05.560 attracted and sent to the tavern to be treated 0: 06: 03.129, 0: 06: 07.930 if you haven’t had time to experiment this 0: 06: 05.560, 0: 06: 10.150 daughter then you miss a lot all the more 0: 06: 07.930, 0: 06: 13.360 Guinevere thank goodness it’s practically 0: 06: 10.150, 0: 06: 15.580 a courage forgotten by my guts like this 0: 06: 13.360, 0: 06: 18.430 and don’t remember when her last day 0: 06: 15.580, 0: 06: 20.800 chagrined by easing friends on my 0: 06: 18.430, 0: 06: 24.900 all thanks to those who subscribed and 0: 06: 20.800, 0: 06: 24.900 shared his opinion happy

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At SWMW Law we take pride in developing relationships with every purchaser who is suffering from mesothelioma. Each purchaser every family has a unique story that causes us to help in every direction we are able to. From the moment we fulfill until your action is resolved. The same friendly face. The same, dedicated spouse will be on your unit, navigating you and your family every step of the room. When you put your confidence in us, we will handle all the heavy lifting. You live your life. While we fight for your claims, We will help you obtain compensation as quickly as possible so that you are eligible to have the peace of mind. Monetary security and justice you deserve. If you or a loved one has been diagnosed with mesothelioma Contact, SWMW Law for a complimentary , no indebtednes consultation today, SWMW helping you and those you adoration

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CT vs. PET Scans for Mesothelioma Patients

Video transcript: What Does That Really Mean? Part 3CT vs. PET Scans Hi, Im Kaylen Jackson and I am the MedicalOutreach Director for the Mesothelioma Center. And on this weeks What Does it ReallyMean, Im going to be going over the difference between a CT Scan, also known asa CAT scan, and a PET Scan, which are two different but related imaging procedures. A CT scan is really useful at yielding us informationabout boney organizes as well as some soft tissue. It rebuts the question what does it looklike. For sample a CT scan is effective at discoveringabnormal emergences or tumors that could indicate mesothelioma. The practice that its done is very similar toan X-ray. In fact it exploits the same technology, exceptthe camera angle is from the top down.And it also provides physicians of a cross-sectionview. So they can see the patient layer by layerand this grants them information about the parts as well as the circumventing tissue. A PET scan on the other hand hands us goodinformation about the running areas of the body. So this answers the question How is itworking? It can be really effective at helping us understandstaging because it presents us informed about how the cancer is growing.It can also help us understand how a treatmentis being effective for individual patients. The path that its done is the patient isinjected with a tracer that then zooms to the most energy consuming areas of the body. And actually when you look at the examinations themselves, its gonna seem really similar to when you tune in to your neighbourhood forecast canal. So youll meet areas of blue and green, aswell of red-hot areas of red and orange. And these are the most energy consuming regions. This is going to be the heart, the brain, as well as any areas where theres rapid cellular expansion which could indicate cancer.If you have any questions or would like anyadditional information please feel free to give us a scold. And thanks for watching ..

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